Butenafine
A topical antifungal of the benzylamine class used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch). It works by inhibiting an enzyme in the fungal cell membrane synthesis pathway called squalene epoxidase, disrupting membrane integrity. It is available as a cream and requires consistent application for full effectiveness.
Masse moléculaire
317,5000 g/mol
LogP
6,30
TPSA
3,20 Ų
Règle des 5 de Lipinski
Conforme
Mécanisme d'action
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Structure 2D
Cite this structure
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SMILES
CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12
InChI
InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3
Molecular Formula
C23H27N
HBD / HBA
- / 1
Liaisons Rotatives
5
Atomes Lourds
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A topical antifungal of the benzylamine class used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch). It works by inhibiting an enzyme in the fungal cell membrane synthesis pathway called squalene epoxidase, disrupting membrane integrity. It is available as a cream and requires consistent application for full effectiveness.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Butenafine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL990. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2484. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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