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Butenafine

CHEMBL990 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
317.5 g/mol
LogP
6.3
Phase
4

A topical antifungal of the benzylamine class used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch). It works by inhibiting an enzyme in the fungal cell membrane synthesis pathway called squalene epoxidase, disrupting membrane integrity. It is available as a cream and requires consistent application for full effectiveness.

分子量

317.5000 g/mol

LogP

6.30

TPSA

3.20 Ų

Lipinski 五规则

符合

作用机制

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

二维结构

SVG PNG

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SMILES

                    
CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12

                

                

                
                

                    
InChI

                    
InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C23H27N

                    

                    
                    

                        
HBD / HBA

                        
- / 1

                    

                    
                    

                        
可旋转键数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
24

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A topical antifungal of the benzylamine class used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch). It works by inhibiting an enzyme in the fungal cell membrane synthesis pathway called squalene epoxidase, disrupting membrane integrity. It is available as a cream and requires consistent application for full effectiveness.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Butenafine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL990.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2484.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.