Cephaloridine
One of the earliest cephalosporin antibiotics, previously used parenterally for gram-positive bacterial infections, now obsolete due to significant nephrotoxicity that limits its safe use. Its renal tubular toxicity made it dangerous at therapeutic doses. It has been entirely replaced by safer cephalosporin generations.
Masse moléculaire
415,5000 g/mol
LogP
1,90
TPSA
147,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Structure 2D
Cite this structure
Embed this structure
SMILES
O=C(Cc1cccs1)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12
InChI
InChI=1S/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)/t15-,18-/m1/s1
Molecular Formula
C19H17N3O4S2
HBD / HBA
1 / 6
Liaisons Rotatives
5
Atomes Lourds
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
One of the earliest cephalosporin antibiotics, previously used parenterally for gram-positive bacterial infections, now obsolete due to significant nephrotoxicity that limits its safe use. Its renal tubular toxicity made it dangerous at therapeutic doses. It has been entirely replaced by safer cephalosporin generations.
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Yes, Cephaloridine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL316157. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5773. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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