Cinacalcet
A calcimimetic agent that increases the sensitivity of the calcium-sensing receptor on parathyroid cells to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. It is used to treat secondary hyperparathyroidism in dialysis patients and hypercalcemia in parathyroid carcinoma. Hypocalcemia is an important adverse effect that requires monitoring of serum calcium levels.
Masse moléculaire
357,4000 g/mol
LogP
6,10
TPSA
12,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Mimics or modulates parathyroid hormone activity to stimulate osteoblast-mediated bone formation, increasing bone mineral density and reducing fracture risk.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Mimics or modulates parathyroid hormone activity to stimulate osteoblast-mediated bone formation, increasing bone mineral density and reducing fracture risk.
Structure 2D
Cite this structure
Embed this structure
SMILES
C[C@@H](NCCCc1cccc(C(F)(F)F)c1)c1cccc2ccccc12
InChI
InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1
Molecular Formula
C22H22F3N
HBD / HBA
1 / 4
Liaisons Rotatives
6
Atomes Lourds
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A calcimimetic agent that increases the sensitivity of the calcium-sensing receptor on parathyroid cells to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. It is used to treat secondary hyperparathyroidism in dialysis patients and hypercalcemia in parathyroid carcinoma. Hypocalcemia is an important adverse effect that requires monitoring of serum calcium levels.
Mimics or modulates parathyroid hormone activity to stimulate osteoblast-mediated bone formation, increasing bone mineral density and reducing fracture risk.
Yes, Cinacalcet is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201284. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 156419. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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