Citric Acid
A naturally occurring tricarboxylic acid widely used in pharmaceutical formulations as an acidulant, buffering agent, antioxidant, and chelating agent. It is also used as a urinary alkalinizer in oral solutions to dissolve uric acid and cystine kidney stones. As a component of anticoagulant solutions, it binds calcium to prevent blood clotting during storage.
Masse moléculaire
192,1200 g/mol
LogP
-1,70
TPSA
132,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Structure 2D
Cite this structure
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SMILES
O=C(O)CC(O)(CC(=O)O)C(=O)O
InChI
InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
Molecular Formula
C6H8O7
HBD / HBA
4 / 7
Liaisons Rotatives
5
Atomes Lourds
13
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A naturally occurring tricarboxylic acid widely used in pharmaceutical formulations as an acidulant, buffering agent, antioxidant, and chelating agent. It is also used as a urinary alkalinizer in oral solutions to dissolve uric acid and cystine kidney stones. As a component of anticoagulant solutions, it binds calcium to prevent blood clotting during storage.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Citric Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1261. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 311. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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