Desoximetasone
A mid-to-high potency topical corticosteroid used to treat inflammatory skin conditions including psoriasis and atopic dermatitis by suppressing local immune responses. It is available in various formulations and should not be used on the face or in skin folds for extended periods.
Masse moléculaire
376,5000 g/mol
LogP
2,30
TPSA
74,60 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Structure 2D
Cite this structure
Embed this structure
SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO
InChI
InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
Molecular Formula
C22H29FO4
HBD / HBA
2 / 5
Liaisons Rotatives
2
Atomes Lourds
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A mid-to-high potency topical corticosteroid used to treat inflammatory skin conditions including psoriasis and atopic dermatitis by suppressing local immune responses. It is available in various formulations and should not be used on the face or in skin folds for extended periods.
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Yes, Desoximetasone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1766. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5311067. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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