Dienestrol
A synthetic nonsteroidal estrogen used topically as a vaginal cream to treat vaginal atrophy and dryness in postmenopausal women. It is structurally related to diethylstilbestrol and restores vaginal tissue health by locally supplementing estrogen. Systemic absorption is minimal with vaginal use at recommended doses.
Masse moléculaire
266,3000 g/mol
LogP
5,40
TPSA
40,50 Ų
Règle des 5 de Lipinski
Conforme
Mécanisme d'action
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Structure 2D
Cite this structure
Embed this structure
SMILES
C/C=C(C(=C/C)/c1ccc(O)cc1)\c1ccc(O)cc1
InChI
InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+
Molecular Formula
C18H18O2
HBD / HBA
2 / 2
Liaisons Rotatives
3
Atomes Lourds
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A synthetic nonsteroidal estrogen used topically as a vaginal cream to treat vaginal atrophy and dryness in postmenopausal women. It is structurally related to diethylstilbestrol and restores vaginal tissue health by locally supplementing estrogen. Systemic absorption is minimal with vaginal use at recommended doses.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Dienestrol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1018. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 667476. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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