Dihydroergotamine Mesylate

CHEMBL1200517 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

679.8 g/mol

LogP

—

Phase

4

The mesylate salt form of dihydroergotamine, used in nasal spray and injectable preparations for acute migraine and cluster headache treatment. The parent compound constricts dilated blood vessels in the brain and reduces neurogenic inflammation. This salt form improves solubility for pharmaceutical formulation.

Masse moléculaire

679,8000 g/mol

TPSA

181,00 Å²

Aires thérapeutiques

Migraine

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21.CS(=O)(=O)O

InChI

InChI=1S/C33H37N5O5.CH4O3S/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32;1-5(2,3)4/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39);1H3,(H,2,3,4)/t21-,23-,25-,26+,27+,32-,33+;/m1./s1

Molecular Formula

C34H41N5O8S

HBD / HBA

4 / 9

Liaisons Rotatives

4

Atomes Lourds

48

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

The mesylate salt form of dihydroergotamine, used in nasal spray and injectable preparations for acute migraine and cluster headache treatment. The parent compound constricts dilated blood vessels in the brain and reduces neurogenic inflammation. This salt form improves solubility for pharmaceutical formulation.

Yes, Dihydroergotamine Mesylate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200517. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 71171. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C34H41N5O8S
Synonymes: 4

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.