Formulation

The process and composition by which an active pharmaceutical ingredient is combined with excipients to create a stable, bioavailable, and manufacturable dosage form. Formulation science addresses challenges including drug solubility, stability, controlled release, taste masking, and patient acceptability. The choice of formulation directly impacts bioavailability, onset of action, and patient compliance.

Exemples

• Amorphous solid dispersion for poorly soluble BCS Class II drugs
• Liposomal formulation of doxorubicin (Doxil) reducing cardiotoxicity
• Extended-release matrix tablet of metformin (Glucophage XR)