Flunitrazepam
This potent benzodiazepine has strong sedative, hypnotic, and muscle-relaxant properties and has been used medically for severe insomnia and as a pre-anesthetic agent. Due to its potential for misuse and association with drug-facilitated assault, it is tightly controlled or banned in many countries.
Masse moléculaire
313,2800 g/mol
LogP
2,10
TPSA
78,50 Ų
Règle des 5 de Lipinski
Conforme
Mécanisme d'action
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …
Structure 2D
Cite this structure
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SMILES
CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21
InChI
InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3
Molecular Formula
C16H12FN3O3
HBD / HBA
- / 5
Liaisons Rotatives
1
Atomes Lourds
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This potent benzodiazepine has strong sedative, hypnotic, and muscle-relaxant properties and has been used medically for severe insomnia and as a pre-anesthetic agent. Due to its potential for misuse and association with drug-facilitated assault, it is tightly controlled or banned in many countries.
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Yes, Flunitrazepam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL13280. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3380. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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