Flunitrazepam

CHEMBL13280 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

313.3 g/mol

LogP

2.1

Phase

4

This potent benzodiazepine has strong sedative, hypnotic, and muscle-relaxant properties and has been used medically for severe insomnia and as a pre-anesthetic agent. Due to its potential for misuse and association with drug-facilitated assault, it is tightly controlled or banned in many countries.

分子量

313.2800 g/mol

LogP

2.10

TPSA

78.50 Å²

Lipinski 五规则

符合

作用机制

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …

二维结构

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SMILES

CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21

InChI

InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3

Molecular Formula

C16H12FN3O3

HBD / HBA

- / 5

可旋转键数

1

重原子数

23

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

This potent benzodiazepine has strong sedative, hypnotic, and muscle-relaxant properties and has been used medically for severe insomnia and as a pre-anesthetic agent. Due to its potential for misuse and association with drug-facilitated assault, it is tightly controlled or banned in many countries.

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.

Yes, Flunitrazepam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL13280. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 3380. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

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分子式: C16H12FN3O3

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.