Hydrocortisone
A synthetic form of the naturally occurring glucocorticoid cortisol, used to treat a wide range of inflammatory and allergic conditions including asthma, eczema, rheumatoid arthritis, and adrenal insufficiency by suppressing immune and inflammatory responses. It is available in topical, oral, inhaled, and injectable formulations for different clinical needs. Long-term systemic use can cause significant metabolic and hormonal side effects.
Masse moléculaire
362,5000 g/mol
LogP
1,60
TPSA
94,80 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Structure 2D
Cite this structure
Embed this structure
SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO
InChI
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Molecular Formula
C21H30O5
HBD / HBA
3 / 5
Liaisons Rotatives
2
Atomes Lourds
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A synthetic form of the naturally occurring glucocorticoid cortisol, used to treat a wide range of inflammatory and allergic conditions including asthma, eczema, rheumatoid arthritis, and adrenal insufficiency by suppressing immune and inflammatory responses. It is available in topical, oral, inhaled, and injectable formulations for different clinical needs. Long-term systemic use can cause significant metabolic and hormonal side effects.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Hydrocortisone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL389621. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5754. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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