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Icosapent Ethyl

CHEMBL2095209 Phase 4 Approuvé Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
330.5 g/mol
LogP
6.3
Phase
4

This purified omega-3 fatty acid ethyl ester, derived from fish oil, is used to reduce cardiovascular risk in adults with elevated triglycerides alongside statin therapy. Unlike other fish oil supplements, it contains only EPA (eicosapentaenoic acid) without DHA, which is thought to contribute to its unique cardiovascular benefits. It has been shown to significantly reduce major adverse cardiovascular events.

Masse moléculaire

330,5000 g/mol

LogP

6,30

TPSA

26,30 Ų

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Cardiovascular Disease Alzheimer's Disease Schizophrenia Bipolar Disorder Inflammatory Bowel Disease Systemic Lupus Erythematosus Non-Alcoholic Fatty Liver Disease Stroke Obesity Type 2 Diabetes Major Depressive Disorder Breast Cancer Heart Failure Colorectal Cancer

Mécanisme d'action

Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mécanisme

Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.

Structure 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OCC

                

                

                
                

                    
InChI

                    
InChI=1S/C22H34O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-4-2/h5-6,8-9,11-12,14-15,17-18H,3-4,7,10,13,16,19-21H2,1-2H3/b6-5-,9-8-,12-11-,15-14-,18-17-

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H34O2

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Liaisons Rotatives

                        
15

                    

                    
                    
                    

                        
Atomes Lourds

                        
24

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Foire aux questions

                

                    
                    

                        
                        

                            
This purified omega-3 fatty acid ethyl ester, derived from fish oil, is used to reduce cardiovascular risk in adults with elevated triglycerides alongside statin therapy. Unlike other fish oil supplements, it contains only EPA (eicosapentaenoic acid) without DHA, which is thought to contribute to its unique cardiovascular benefits. It has been shown to significantly reduce major adverse cardiovascular events.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Icosapent Ethyl is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2095209.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9831415.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Avertissement médical

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.