Ipratropium
This anticholinergic bronchodilator is used to relieve bronchospasm in COPD and asthma by blocking muscarinic receptors in the airways, preventing the smooth muscle constriction caused by the vagal nerve. It helps open the airways and reduce mucus secretion. It is available in inhaled forms for maintenance therapy and is often combined with short-acting beta-agonists.
Masse moléculaire
332,5000 g/mol
LogP
2,60
TPSA
46,50 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.
Structure 2D
Cite this structure
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SMILES
CC(C)[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2
InChI
InChI=1S/C20H30NO3/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15/h4-8,14,16-19,22H,9-13H2,1-3H3/q+1/t16-,17+,18+,19?,21?
Molecular Formula
C20H30NO3+
HBD / HBA
1 / 3
Liaisons Rotatives
6
Atomes Lourds
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This anticholinergic bronchodilator is used to relieve bronchospasm in COPD and asthma by blocking muscarinic receptors in the airways, preventing the smooth muscle constriction caused by the vagal nerve. It helps open the airways and reduce mucus secretion. It is available in inhaled forms for maintenance therapy and is often combined with short-acting beta-agonists.
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.
Yes, Ipratropium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1621597. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 657309. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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