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Isoflurane

CHEMBL1256 Phase 4 Approuvé Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
184.5 g/mol
LogP
2.1
Phase
4

This halogenated ether is a widely used inhaled general anesthetic that maintains unconsciousness, muscle relaxation, and analgesia during surgery. It works by modulating multiple ion channels and neurotransmitter systems throughout the central nervous system. It is administered through a vaporizer in a precise concentration calibrated to the patient's needs.

Masse moléculaire

184,4900 g/mol

LogP

2,10

TPSA

9,20 Ų

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Cardiovascular Disease Pain Management Non-Small Cell Lung Cancer Chronic Obstructive Pulmonary Disease Alzheimer's Disease Parkinson's Disease Melanoma Oncology Obstetrics & Gynecology Non-Alcoholic Fatty Liver Disease Stroke Type 2 Diabetes Hypertension Chronic Pain Colorectal Cancer

Mécanisme d'action

Produces reversible loss of consciousness and sensation through modulation of neuronal ion channels and receptor systems in the central nervous system, including GABA-A enhancement and NMDA receptor inhibition.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mécanisme

Produces reversible loss of consciousness and sensation through modulation of neuronal ion channels and receptor systems in the central nervous system, including GABA-A enhancement and NMDA receptor inhibition.

Structure 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
FC(F)OC(Cl)C(F)(F)F

                

                

                
                

                    
InChI

                    
InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H

                

                

                

                    
                    

                        
Molecular Formula

                        
C3H2ClF5O

                    

                    
                    

                        
HBD / HBA

                        
- / 6

                    

                    
                    

                        
Liaisons Rotatives

                        
2

                    

                    
                    
                    

                        
Atomes Lourds

                        
10

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Foire aux questions

                

                    
                    

                        
                        

                            
This halogenated ether is a widely used inhaled general anesthetic that maintains unconsciousness, muscle relaxation, and analgesia during surgery. It works by modulating multiple ion channels and neurotransmitter systems throughout the central nervous system. It is administered through a vaporizer in a precise concentration calibrated to the patient's needs.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Produces reversible loss of consciousness and sensation through modulation of neuronal ion channels and receptor systems in the central nervous system, including GABA-A enhancement and NMDA receptor inhibition.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Isoflurane is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1256.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3763.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Avertissement médical

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.