Lovastatin
A naturally occurring statin originally derived from fungus, used to lower LDL cholesterol and reduce the risk of cardiovascular events, and studied for potential anticancer and neuroprotective effects. It inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis.
Masse moléculaire
404,5390 g/mol
LogP
4,30
TPSA
72,80 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Classes de médicaments
Mécanisme d'action
First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.
Structure 2D
Cite this structure
Embed this structure
SMILES
CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21
InChI
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
Molecular Formula
C24H36O5
HBD / HBA
1 / 5
Liaisons Rotatives
7
Atomes Lourds
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A naturally occurring statin originally derived from fungus, used to lower LDL cholesterol and reduce the risk of cardiovascular events, and studied for potential anticancer and neuroprotective effects. It inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis.
First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.
Key pharmacokinetic parameters for Lovastatin: Half-life: 2-3 hours.
Yes, Lovastatin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL503. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 53232. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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