Mebendazole
An antiparasitic medication primarily used to treat intestinal worm infections such as pinworms, roundworms, and hookworms, and is also being studied for potential anticancer properties. It works by disrupting the formation of microtubules in parasites and potentially in cancer cells.
Masse moléculaire
295,2900 g/mol
LogP
2,80
TPSA
84,10 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Structure 2D
Cite this structure
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SMILES
COC(=O)Nc1nc2cc(C(=O)c3ccccc3)ccc2[nH]1
InChI
InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)
Molecular Formula
C16H13N3O3
HBD / HBA
2 / 4
Liaisons Rotatives
4
Atomes Lourds
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
An antiparasitic medication primarily used to treat intestinal worm infections such as pinworms, roundworms, and hookworms, and is also being studied for potential anticancer properties. It works by disrupting the formation of microtubules in parasites and potentially in cancer cells.
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Yes, Mebendazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL685. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4030. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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