Menthol
This naturally occurring compound from peppermint and other mint plants creates a cooling sensation by activating cold-sensitive nerve receptors (TRPM8 channels) without actually changing temperature, making it widely used in topical pain relievers, cough drops, and skin care products. When applied to the skin or mucous membranes, it can temporarily relieve minor pain, itching, and congestion.
Masse moléculaire
156,2600 g/mol
LogP
3,00
TPSA
20,20 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Structure 2D
Cite this structure
Embed this structure
SMILES
CC1CCC(C(C)C)C(O)C1
InChI
InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3
Molecular Formula
C10H20O
HBD / HBA
1 / 1
Liaisons Rotatives
1
Atomes Lourds
11
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This naturally occurring compound from peppermint and other mint plants creates a cooling sensation by activating cold-sensitive nerve receptors (TRPM8 channels) without actually changing temperature, making it widely used in topical pain relievers, cough drops, and skin care products. When applied to the skin or mucous membranes, it can temporarily relieve minor pain, itching, and congestion.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Menthol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL256087. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 1254. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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