Pifoxime
Pifoxime is an oxime derivative with cholinesterase reactivating properties that was investigated as a treatment for organophosphate poisoning by regenerating inhibited acetylcholinesterase at neuromuscular junctions and in the central nervous system. Its clinical development was limited relative to pralidoxime, which became the standard oxime reactivator in organophosphate toxicity management.
Masse moléculaire
276,3300 g/mol
LogP
1,80
TPSA
62,10 Ų
Règle des 5 de Lipinski
Conforme
Mécanisme d'action
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Structure 2D
Cite this structure
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SMILES
C/C(=N\O)c1ccc(OCC(=O)N2CCCCC2)cc1
InChI
InChI=1S/C15H20N2O3/c1-12(16-19)13-5-7-14(8-6-13)20-11-15(18)17-9-3-2-4-10-17/h5-8,19H,2-4,9-11H2,1H3/b16-12+
Molecular Formula
C15H20N2O3
HBD / HBA
1 / 4
Liaisons Rotatives
4
Atomes Lourds
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Pifoxime is an oxime derivative with cholinesterase reactivating properties that was investigated as a treatment for organophosphate poisoning by regenerating inhibited acetylcholinesterase at neuromuscular junctions and in the central nervous system. Its clinical development was limited relative to pralidoxime, which became the standard oxime reactivator in organophosphate toxicity management.
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Yes, Pifoxime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1998966. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 35755. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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