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Pifoxime

CHEMBL1998966 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
276.3 g/mol
LogP
1.8
Phase
4

Pifoxime is an oxime derivative with cholinesterase reactivating properties that was investigated as a treatment for organophosphate poisoning by regenerating inhibited acetylcholinesterase at neuromuscular junctions and in the central nervous system. Its clinical development was limited relative to pralidoxime, which became the standard oxime reactivator in organophosphate toxicity management.

Khối lượng phân tử

276,3300 g/mol

LogP

1,80

TPSA

62,10 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Neurology

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

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SMILES

                    
C/C(=N\O)c1ccc(OCC(=O)N2CCCCC2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C15H20N2O3/c1-12(16-19)13-5-7-14(8-6-13)20-11-15(18)17-9-3-2-4-10-17/h5-8,19H,2-4,9-11H2,1H3/b16-12+

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H20N2O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 4

                    

                    
                    

                        
Liên kết có thể quay

                        
4

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Pifoxime is an oxime derivative with cholinesterase reactivating properties that was investigated as a treatment for organophosphate poisoning by regenerating inhibited acetylcholinesterase at neuromuscular junctions and in the central nervous system. Its clinical development was limited relative to pralidoxime, which became the standard oxime reactivator in organophosphate toxicity management.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Pifoxime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1998966.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 35755.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.