Prilocaine
Prilocaine is an amide-type local anesthetic that reversibly blocks voltage-gated sodium channels in nerve membranes, preventing sodium ion influx and thereby inhibiting generation and conduction of action potentials. It is used for infiltration anesthesia, nerve blocks, epidural anesthesia, and in combination with lidocaine as a topical eutectic mixture (EMLA) for skin analgesia.
Masse moléculaire
220,3100 g/mol
LogP
2,10
TPSA
41,10 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Structure 2D
Cite this structure
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SMILES
CCCNC(C)C(=O)Nc1ccccc1C
InChI
InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
Molecular Formula
C13H20N2O
HBD / HBA
2 / 2
Liaisons Rotatives
5
Atomes Lourds
16
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Prilocaine is an amide-type local anesthetic that reversibly blocks voltage-gated sodium channels in nerve membranes, preventing sodium ion influx and thereby inhibiting generation and conduction of action potentials. It is used for infiltration anesthesia, nerve blocks, epidural anesthesia, and in combination with lidocaine as a topical eutectic mixture (EMLA) for skin analgesia.
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Yes, Prilocaine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1194. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4906. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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