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Prilocaine

CHEMBL1194 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
220.3 g/mol
LogP
2.1
Phase
4

Prilocaine is an amide-type local anesthetic that reversibly blocks voltage-gated sodium channels in nerve membranes, preventing sodium ion influx and thereby inhibiting generation and conduction of action potentials. It is used for infiltration anesthesia, nerve blocks, epidural anesthesia, and in combination with lidocaine as a topical eutectic mixture (EMLA) for skin analgesia.

น้ำหนักโมเลกุล

220.3100 g/mol

LogP

2.10

TPSA

41.10 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Glaucoma Dermatology Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Migraine Generalized Anxiety Disorder Melanoma Stroke Obesity Lymphoma Breast Cancer Gout Chronic Pain Tuberculosis Prostate Cancer Colorectal Cancer Leukemia

กลไกการออกฤทธิ์

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCNC(C)C(=O)Nc1ccccc1C

                

                

                
                

                    
InChI

                    
InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H20N2O

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
พันธะที่หมุนได้

                        
5

                    

                    
                    
                    

                        
อะตอมหนัก

                        
16

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Prilocaine is an amide-type local anesthetic that reversibly blocks voltage-gated sodium channels in nerve membranes, preventing sodium ion influx and thereby inhibiting generation and conduction of action potentials. It is used for infiltration anesthesia, nerve blocks, epidural anesthesia, and in combination with lidocaine as a topical eutectic mixture (EMLA) for skin analgesia.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Prilocaine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1194.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4906.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.