Prucalopride
Prucalopride is a highly selective serotonin 5-HT4 receptor agonist that stimulates colonic motility and accelerates gastrointestinal transit by activating enteric nervous system pathways, promoting coordinated peristaltic reflexes throughout the large intestine. It is approved for the treatment of chronic idiopathic constipation in adults who have not responded adequately to laxatives.
Masse moléculaire
367,9000 g/mol
LogP
2,00
TPSA
76,80 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Structure 2D
Cite this structure
Embed this structure
SMILES
COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1
InChI
InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
Molecular Formula
C18H26ClN3O3
HBD / HBA
2 / 5
Liaisons Rotatives
6
Atomes Lourds
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Prucalopride is a highly selective serotonin 5-HT4 receptor agonist that stimulates colonic motility and accelerates gastrointestinal transit by activating enteric nervous system pathways, promoting coordinated peristaltic reflexes throughout the large intestine. It is approved for the treatment of chronic idiopathic constipation in adults who have not responded adequately to laxatives.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Prucalopride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL117287. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3052762. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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