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Prucalopride

CHEMBL117287 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
367.9 g/mol
LogP
2.0
Phase
4

Prucalopride is a highly selective serotonin 5-HT4 receptor agonist that stimulates colonic motility and accelerates gastrointestinal transit by activating enteric nervous system pathways, promoting coordinated peristaltic reflexes throughout the large intestine. It is approved for the treatment of chronic idiopathic constipation in adults who have not responded adequately to laxatives.

Khối lượng phân tử

367,9000 g/mol

LogP

2,00

TPSA

76,80 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Bladder Cancer Schizophrenia Gastroesophageal Reflux Disease Inflammatory Bowel Disease Major Depressive Disorder Colorectal Cancer

Cơ chế tác dụng

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1

                

                

                
                

                    
InChI

                    
InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H26ClN3O3

                    

                    
                    

                        
HBD / HBA

                        
2 / 5

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Prucalopride is a highly selective serotonin 5-HT4 receptor agonist that stimulates colonic motility and accelerates gastrointestinal transit by activating enteric nervous system pathways, promoting coordinated peristaltic reflexes throughout the large intestine. It is approved for the treatment of chronic idiopathic constipation in adults who have not responded adequately to laxatives.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Prucalopride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL117287.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3052762.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.