Ropeginterferon Alfa-2B
Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon alfa-2b with antiviral and antiproliferative properties, used for the treatment of polycythemia vera and chronic hepatitis C. It acts by binding to cell surface receptors to activate the JAK-STAT signaling pathway, suppressing viral replication and abnormal cell proliferation. Its extended half-life allows for less frequent dosing compared to conventional interferons.
Masse moléculaire
447,5000 g/mol
LogP
-1,30
TPSA
136,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Pharmacokinetics (PK)
Pharmacodynamics (PD)
SMILES
COCCOC(=O)NCCCCC(CCN1CCC[C@H]1C(=O)O)NC(=O)OCCOC
InChI
InChI=1S/C20H37N3O8/c1-28-12-14-30-19(26)21-9-4-3-6-16(22-20(27)31-15-13-29-2)8-11-23-10-5-7-17(23)18(24)25/h16-17H,3-15H2,1-2H3,(H,21,26)(H,22,27)(H,24,25)/t16?,17-/m0/s1
Molecular Formula
C20H37N3O8
HBD / HBA
3 / 9
Liaisons Rotatives
18
Atomes Lourds
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon alfa-2b with antiviral and antiproliferative properties, used for the treatment of polycythemia vera and chronic hepatitis C. It acts by binding to cell surface receptors to activate the JAK-STAT signaling pathway, suppressing viral replication and abnormal cell proliferation. Its extended half-life allows for less frequent dosing compared to conventional interferons.
Yes, Ropeginterferon Alfa-2B is an approved drug. It has reached clinical phase 4. It is classified as a Protein.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297819. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 86278347. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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