Sodium Zirconium Cyclosilicate
Sodium zirconium cyclosilicate is a selective potassium-capturing ion exchange compound used for the treatment of hyperkalemia in chronic kidney disease and heart failure. The microporous zirconium silicate framework selectively captures potassium ions (and ammonium ions) in the gastrointestinal tract in exchange for sodium and hydrogen ions, reducing intestinal potassium absorption and lowering serum potassium levels. Unlike older potassium binders, it has high selectivity for potassium over calcium and magnesium.
Masse moléculaire
365,4500 g/mol
TPSA
166,00 Ų
Aires thérapeutiques
Pharmacokinetics (PK)
Pharmacodynamics (PD)
SMILES
[O-][Si]1(O[Si](O[Si](O1)([O-])[O-])([O-])[O-])[O-].[Na+].[Na+].[Zr+4]
InChI
InChI=1S/2Na.O9Si3.Zr/c;;1-10(2)7-11(3,4)9-12(5,6)8-10;/q2*+1;-6;+4
Molecular Formula
Na2O9Si3Zr
HBD / HBA
- / 9
Liaisons Rotatives
0
Atomes Lourds
15
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Sodium zirconium cyclosilicate is a selective potassium-capturing ion exchange compound used for the treatment of hyperkalemia in chronic kidney disease and heart failure. The microporous zirconium silicate framework selectively captures potassium ions (and ammonium ions) in the gastrointestinal tract in exchange for sodium and hydrogen ions, reducing intestinal potassium absorption and lowering serum potassium levels. Unlike older potassium binders, it has high selectivity for potassium over calcium and magnesium.
Yes, Sodium Zirconium Cyclosilicate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3301592. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 155804812. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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