Thiamylal
Thiamylal is an ultra-short-acting barbiturate anesthetic that acts on GABA-A receptors to potentiate chloride ion influx, producing rapid induction of general anesthesia when administered intravenously. It was used as an induction agent for surgical anesthesia before the widespread adoption of propofol, offering rapid onset and recovery due to rapid redistribution from the brain to peripheral tissues. Its use has largely been replaced by propofol due to the latter's superior pharmacokinetic profile and recovery characteristics.
Masse moléculaire
254,3500 g/mol
LogP
3,20
TPSA
90,30 Ų
Règle des 5 de Lipinski
Conforme
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Structure 2D
Cite this structure
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SMILES
C=CCC1(C(C)CCC)C(=O)NC(=S)NC1=O
InChI
InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)
Molecular Formula
C12H18N2O2S
HBD / HBA
2 / 3
Liaisons Rotatives
5
Atomes Lourds
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Thiamylal is an ultra-short-acting barbiturate anesthetic that acts on GABA-A receptors to potentiate chloride ion influx, producing rapid induction of general anesthesia when administered intravenously. It was used as an induction agent for surgical anesthesia before the widespread adoption of propofol, offering rapid onset and recovery due to rapid redistribution from the brain to peripheral tissues. Its use has largely been replaced by propofol due to the latter's superior pharmacokinetic profile and recovery characteristics.
Yes, Thiamylal is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL440. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3032285. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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