Tirofiban
Tirofiban is a non-peptide glycoprotein IIb/IIIa (αIIbβ3 integrin) receptor antagonist that blocks the binding of fibrinogen, von Willebrand factor, and other adhesive proteins to activated platelet receptors, preventing platelet aggregation and thrombus formation. It is used intravenously in combination with heparin for the management of acute coronary syndromes (unstable angina and NSTEMI) and percutaneous coronary intervention. Its reversible binding and short duration of action allow rapid recovery of platelet function after discontinuation.
Masse moléculaire
440,6000 g/mol
LogP
1,40
TPSA
113,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Structure 2D
Cite this structure
Embed this structure
SMILES
CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O
InChI
InChI=1S/C22H36N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26)/t21-/m0/s1
Molecular Formula
C22H36N2O5S
HBD / HBA
3 / 7
Liaisons Rotatives
14
Atomes Lourds
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Tirofiban is a non-peptide glycoprotein IIb/IIIa (αIIbβ3 integrin) receptor antagonist that blocks the binding of fibrinogen, von Willebrand factor, and other adhesive proteins to activated platelet receptors, preventing platelet aggregation and thrombus formation. It is used intravenously in combination with heparin for the management of acute coronary syndromes (unstable angina and NSTEMI) and percutaneous coronary intervention. Its reversible binding and short duration of action allow rapid recovery of platelet function after discontinuation.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Tirofiban is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL916. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 60947. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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