Trientine
Trientine (triethylenetetramine, TETA) is a polyamine copper-chelating agent that forms stable complexes with copper ions, promoting urinary copper excretion and reducing systemic copper accumulation in Wilson's disease (hepatolenticular degeneration), a genetic disorder of copper metabolism due to ATP7B mutations. It is used as an alternative to penicillamine in patients who are intolerant to or who fail penicillamine therapy. Its chelation of excess hepatic and systemic copper prevents oxidative liver injury and neurological damage characteristic of untreated Wilson's disease.
Masse moléculaire
146,2300 g/mol
LogP
-2,50
TPSA
76,10 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Structure 2D
Cite this structure
Embed this structure
SMILES
NCCNCCNCCN
InChI
InChI=1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2
Molecular Formula
C6H18N4
HBD / HBA
4 / 4
Liaisons Rotatives
7
Atomes Lourds
10
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
Trientine (triethylenetetramine, TETA) is a polyamine copper-chelating agent that forms stable complexes with copper ions, promoting urinary copper excretion and reducing systemic copper accumulation in Wilson's disease (hepatolenticular degeneration), a genetic disorder of copper metabolism due to ATP7B mutations. It is used as an alternative to penicillamine in patients who are intolerant to or who fail penicillamine therapy. Its chelation of excess hepatic and systemic copper prevents oxidative liver injury and neurological damage characteristic of untreated Wilson's disease.
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Yes, Trientine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL609. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5565. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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