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Trientine

CHEMBL609 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
146.2 g/mol
LogP
-2.5
Phase
4

Trientine (triethylenetetramine, TETA) is a polyamine copper-chelating agent that forms stable complexes with copper ions, promoting urinary copper excretion and reducing systemic copper accumulation in Wilson's disease (hepatolenticular degeneration), a genetic disorder of copper metabolism due to ATP7B mutations. It is used as an alternative to penicillamine in patients who are intolerant to or who fail penicillamine therapy. Its chelation of excess hepatic and systemic copper prevents oxidative liver injury and neurological damage characteristic of untreated Wilson's disease.

น้ำหนักโมเลกุล

146.2300 g/mol

LogP

-2.50

TPSA

76.10 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Melanoma

กลไกการออกฤทธิ์

Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
NCCNCCNCCN

                

                

                
                

                    
InChI

                    
InChI=1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H18N4

                    

                    
                    

                        
HBD / HBA

                        
4 / 4

                    

                    
                    

                        
พันธะที่หมุนได้

                        
7

                    

                    
                    
                    

                        
อะตอมหนัก

                        
10

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Trientine (triethylenetetramine, TETA) is a polyamine copper-chelating agent that forms stable complexes with copper ions, promoting urinary copper excretion and reducing systemic copper accumulation in Wilson's disease (hepatolenticular degeneration), a genetic disorder of copper metabolism due to ATP7B mutations. It is used as an alternative to penicillamine in patients who are intolerant to or who fail penicillamine therapy. Its chelation of excess hepatic and systemic copper prevents oxidative liver injury and neurological damage characteristic of untreated Wilson's disease.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Trientine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL609.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5565.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.