Zafirlukast
This leukotriene receptor antagonist is taken as a daily oral tablet to prevent asthma symptoms and reduce the need for rescue inhalers. It works by blocking leukotrienes, inflammatory chemicals that cause airway narrowing, mucus production, and swelling in asthma. It is not for immediate relief of an asthma attack and should be continued even when symptoms are absent.
Masse moléculaire
575,7000 g/mol
LogP
5,50
TPSA
124,00 Ų
Règle des 5 de Lipinski
Non conforme
Aires thérapeutiques
Mécanisme d'action
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Structure 2D
Cite this structure
Embed this structure
SMILES
COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12
InChI
InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
Molecular Formula
C31H33N3O6S
HBD / HBA
2 / 6
Liaisons Rotatives
9
Atomes Lourds
41
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This leukotriene receptor antagonist is taken as a daily oral tablet to prevent asthma symptoms and reduce the need for rescue inhalers. It works by blocking leukotrienes, inflammatory chemicals that cause airway narrowing, mucus production, and swelling in asthma. It is not for immediate relief of an asthma attack and should be continued even when symptoms are absent.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Zafirlukast is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL603. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5717. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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