Area Under the Curve (AUC)
AUCThe integral of the plasma concentration-time curve, representing total drug exposure. AUC0-inf is used for single-dose studies, AUC0-tau for steady-state. Primary measure of bioavailability and bioequivalence.
Exemples
- AUC0-24h for daily dosing
- AUC ratio for bioequivalence (80-125%)
- Dose-normalized AUC
Le saviez-vous ?
The integral of the plasma concentration-time curve, representing total drug exposure. AUC0-inf is used for single-dose studies, AUC0-tau for steady-state. Primary measure of bioavailability and bioequivalence.