Interleukin (IL)

A group of signaling cytokines primarily produced by leukocytes that regulate immune cell differentiation, proliferation, and function. Over 40 interleukins (IL-1 through IL-41) have been identified, mediating both pro-inflammatory (IL-1, IL-6, IL-17) and anti-inflammatory (IL-10, IL-4) responses. Multiple interleukin-targeted therapies are approved for autoimmune and inflammatory conditions.

Exemples

• Secukinumab — anti-IL-17A (psoriasis, ankylosing spondylitis)
• Dupilumab — anti-IL-4/IL-13 receptor (atopic dermatitis, asthma)
• Anakinra — IL-1 receptor antagonist (rheumatoid arthritis, CAPS)