Lead Optimization
The medicinal chemistry process of modifying a lead compound to improve potency, selectivity, ADME properties, and safety while maintaining drug-likeness. Iterative design-make-test-analyze cycles.
Exemples
- Improving metabolic stability
- Reducing hERG liability
- Enhancing oral bioavailability
Le saviez-vous ?
The medicinal chemistry process of modifying a lead compound to improve potency, selectivity, ADME properties, and safety while maintaining drug-likeness. Iterative design-make-test-analyze cycles.