Network Pharmacology

A computational framework that analyzes drug action through biological networks including protein-protein interaction networks, signaling pathways, and gene regulatory networks. Network pharmacology shifts the paradigm from 'one drug, one target' to understanding multi-target effects and polypharmacology. It uses graph theory, network topology analysis, and pathway enrichment to identify key nodes and predict drug effects.

Exemples

• Cytoscape — open-source platform for network visualization and analysis
• STRING database for protein-protein interaction networks
• Network pharmacology analysis of traditional Chinese medicine formulations