Minor
Suspected
Description
Memantine may compete with metformin for renal tubular cationic secretion, potentially increasing metformin plasma concentrations modestly.
Mécanisme
Memantine and metformin are both organic cation transporter (OCT) substrates and are eliminated via renal tubular secretion; competition at OCT2 may reduce metformin clearance.
Signification clinique
The interaction is generally minor but may be relevant in patients with renal impairment where both drug accumulations could be additive.
Prise en charge
Monitor renal function and blood glucose in patients taking both drugs, especially if renal function declines.