Minor
Suspected
Mô tả
Memantine may compete with metformin for renal tubular cationic secretion, potentially increasing metformin plasma concentrations modestly.
Cơ chế
Memantine and metformin are both organic cation transporter (OCT) substrates and are eliminated via renal tubular secretion; competition at OCT2 may reduce metformin clearance.
Ý nghĩa lâm sàng
The interaction is generally minor but may be relevant in patients with renal impairment where both drug accumulations could be additive.
Xử trí
Monitor renal function and blood glucose in patients taking both drugs, especially if renal function declines.