Major
Probable
Description
Quetiapine combined with morphine significantly increases CNS and respiratory depression, creating a high-risk combination for overdose.
Mécanisme
Quetiapine has sedative CNS effects via H1, alpha-1, and D2 receptor blockade; additive with opioid mu-receptor-mediated CNS depression.
Signification clinique
Case series document fatal respiratory depression with opioid-quetiapine combinations; FDA has issued safety communications on antipsychotic-opioid risk.
Prise en charge
Avoid combination or use with extreme caution; monitor respiratory function closely and provide naloxone access.