Loading Dose

Pharmacokinetics

An initial higher dose given to rapidly achieve therapeutic plasma concentrations before steady state. Calculated as Vd * target concentration / bioavailability.

Examples

Digoxin 0.5-1mg loading
Amiodarone IV loading
Phenytoin 15-20mg/kg loading

Did You Know?

An initial higher dose given to rapidly achieve therapeutic plasma concentrations before steady state. Calculated as Vd * target concentration / bioavailability.