MATE1 (MATE1)
MATE1Multidrug and Toxin Extrusion Protein 1 (gene: SLC47A1), a proton/organic cation antiporter expressed on the apical (luminal) membrane of renal proximal tubule cells and hepatic canalicular membrane. Functions as the final efflux step in renal tubular secretion of organic cations, working in tandem with basolateral OCT2. Essential for metformin renal elimination and a site of clinically relevant drug-drug interactions.
Examples
- Metformin luminal efflux in proximal tubule (OCT2 uptake + MATE1 efflux)
- Pyrimethamine inhibition of MATE1 increasing metformin exposure
- Cimetidine dual OCT2/MATE1 inhibition
Did You Know?
Multidrug and Toxin Extrusion Protein 1 (gene: SLC47A1), a proton/organic cation antiporter expressed on the apical (luminal) membrane of renal proximal tubule cells and hepatic canalicular membrane. Functions as the …