MATE2-K (MATE2-K)

Multidrug and Toxin Extrusion Protein 2-K (gene: SLC47A2), a kidney-specific proton/organic cation antiporter expressed on the apical membrane of renal proximal tubule cells. Functions alongside MATE1 as an efflux transporter for organic cations from tubular cells into urine. The kidney-specific splice variant (MATE2-K) is the dominant renal isoform and contributes to metformin tubular secretion.

Examples

• Metformin renal secretion (complementary to MATE1)
• SLC47A2 polymorphisms affecting metformin response in diabetes
• Topotecan renal clearance via MATE2-K efflux