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Narrow Therapeutic Index (NTI)

NTI
General

A drug for which small changes in dose or blood concentration can lead to serious therapeutic failures or adverse effects. Requires careful dose titration, therapeutic drug monitoring, and bioequivalence scrutiny.

Examples

  • Warfarin
  • Lithium
  • Digoxin
  • Phenytoin
  • Cyclosporine

Did You Know?

A drug for which small changes in dose or blood concentration can lead to serious therapeutic failures or adverse effects. Requires careful dose titration, therapeutic drug monitoring, and bioequivalence scrutiny.