Captopril vs Duloxetine

## Captopril vs Duloxetine: Overview

This comparison examines the pharmacological differences between **Captopril** and **Duloxetine**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Duloxetine — 12 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Duloxetine — C18H19NOS.

**Molecular Weight**: Captopril — 217.2850 g/mol; Duloxetine — 297.4150 g/mol.

**Type**: Captopril — Small molecule; Duloxetine — Small molecule.