Captopril vs Trimethoprim

## Captopril vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Captopril** and **Trimethoprim**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Captopril — 217.2850 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Captopril — Small molecule; Trimethoprim — Small molecule.