Hydrochlorothiazide vs Lovastatin

## Hydrochlorothiazide vs Lovastatin: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Lovastatin**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Lovastatin**: First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Lovastatin — 2-3 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Lovastatin — C24H36O5.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Lovastatin — 404.5390 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Lovastatin — Small molecule.