Hydrochlorothiazide vs Ramipril

## Hydrochlorothiazide vs Ramipril: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Ramipril**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Ramipril**: Prodrug converted to ramiprilat; ACE inhibitor.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Ramipril — 13-17 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Ramipril — C23H32N2O5.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Ramipril — 416.5120 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Ramipril — Small molecule.