Hydrochlorothiazide vs Simvastatin

## Hydrochlorothiazide vs Simvastatin: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Simvastatin**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Simvastatin**: Prodrug converted to active form that inhibits HMG-CoA reductase.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Simvastatin — 2 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Simvastatin — C25H38O5.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Simvastatin — 418.5700 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Simvastatin — Small molecule.