Cabozantinib
A multikinase inhibitor that blocks several receptors including VEGFR, MET, and RET involved in tumor growth and spread. It is used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer. Side effects include hypertension, diarrhea, hand-foot skin reaction, and liver function abnormalities.
आणविक भार
501.5000 g/mol
LogP
5.40
TPSA
98.80 Ų
लिपिंस्की RO5
अनुत्तीर्ण
चिकित्सीय क्षेत्र
क्रिया का तंत्र
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
2D संरचना
Cite this structure
Embed this structure
SMILES
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC
InChI
InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
Molecular Formula
C28H24FN3O5
HBD / HBA
2 / 7
घूर्णनीय बंधन
8
भारी परमाणु
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
अक्सर पूछे जाने वाले प्रश्न
A multikinase inhibitor that blocks several receptors including VEGFR, MET, and RET involved in tumor growth and spread. It is used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer. Side effects include hypertension, diarrhea, hand-foot skin reaction, and liver function abnormalities.
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
Yes, Cabozantinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105717. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 25102847. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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