Cabozantinib
A multikinase inhibitor that blocks several receptors including VEGFR, MET, and RET involved in tumor growth and spread. It is used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer. Side effects include hypertension, diarrhea, hand-foot skin reaction, and liver function abnormalities.
分子量
501.5000 g/mol
LogP
5.40
TPSA
98.80 Ų
Lipinski 五规则
不符合
治疗领域
作用机制
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
二维结构
Cite this structure
Embed this structure
SMILES
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC
InChI
InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
Molecular Formula
C28H24FN3O5
HBD / HBA
2 / 7
可旋转键数
8
重原子数
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A multikinase inhibitor that blocks several receptors including VEGFR, MET, and RET involved in tumor growth and spread. It is used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer. Side effects include hypertension, diarrhea, hand-foot skin reaction, and liver function abnormalities.
Inhibits vascular endothelial growth factor (VEGF) signaling, blocking angiogenesis (new blood vessel formation) that tumors require for growth and metastasis.
Yes, Cabozantinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105717. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 25102847. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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