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Cephalexin

CHEMBL1200544 Phase 4 अनुमोदित Small molecule
Half-Life
0.5-1.2 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
347.4 g/mol
LogP
0.6
Phase
4

A first-generation oral cephalosporin antibiotic that inhibits bacterial cell wall synthesis, used for skin and soft tissue infections, respiratory tract infections, urinary tract infections, and streptococcal pharyngitis. It is particularly effective against gram-positive organisms such as Staphylococcus and Streptococcus species. It is generally well tolerated and widely used in community medicine.

आणविक भार

347.3890 g/mol

LogP

0.60

TPSA

138.00 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

एटोपिक डर्मेटाइटिस (एक्जिमा) क्रॉनिक किडनी डिज़ीज़ क्षय रोग (ट्यूबरकुलोसिस) टाइप 2 मधुमेह बिनाइन प्रोस्टेटिक हाइपरप्लासिया मूत्राशय कैंसर मोटापा ल्यूकेमिया संक्रामक रोग स्तन कैंसर हृदय विफलता

दवा वर्ग

J — J - प्रणालीगत उपयोग हेतु एंटीइन्फेक्टिव

क्रिया का तंत्र

First-generation cephalosporin inhibiting cell wall synthesis.

Pharmacokinetics (PK)

Half-Life 0.5-1.2 hours

Pharmacodynamics (PD)

तंत्र

First-generation cephalosporin inhibiting cell wall synthesis.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1.O

                

                

                
                

                    
InChI

                    
InChI=1S/C16H17N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15-;/m1./s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H17N3O4S

                    

                    
                    

                        
HBD / HBA

                        
3 / 6

                    

                    
                    

                        
घूर्णनीय बंधन

                        
4

                    

                    
                    
                    

                        
भारी परमाणु

                        
24

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            ABCB1 (P-ग्लाइकोप्रोटीन)
                            Substrate
                        

                        
                        Primary Target
                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Minor


                            
                                Cephalexin + Ranitidine
                            
                        

                        
                        
Ranitidine may reduce the absorption rate of cephalexin by raising gastric pH, but overall bioavailability is not substantially altered, making this interaction clinically insignificant.

                        
                    
                    
                    
                        

                            

  
  Minor


                            
                                Cephalexin + Metformin
                            
                        

                        
                        
Cephalexin competes with metformin for renal tubular secretion via OCT2 and MATE transporters, which can modestly increase metformin plasma concentrations and its renal clearance.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Cephalexin + Warfarin
                            
                        

                        
                        
Cephalexin may enhance the anticoagulant effect of warfarin, with case reports describing INR elevation during concurrent therapy, likely through disruption of vitamin K-producing gut flora.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
A first-generation oral cephalosporin antibiotic that inhibits bacterial cell wall synthesis, used for skin and soft tissue infections, respiratory tract infections, urinary tract infections, and streptococcal pharyngitis. It is particularly effective against gram-positive organisms such as Staphylococcus and Streptococcus species. It is generally well tolerated and widely used in community medicine.

                        

                    

                    

                    

                    
                    

                        
                        

                            
First-generation cephalosporin inhibiting cell wall synthesis.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Cephalexin: Half-life: 0.5-1.2 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Cephalexin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Amoxicillin
                            Small molecule
                        
                        
                        
                            Azithromycin
                            Small molecule
                        
                        
                        
                            Ciprofloxacin
                            Small molecule
                        
                        
                        
                            Doxycycline
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200544.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 27447.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.